Description
TB-500 10mg
TB-500 is a synthetic peptide fragment derived from Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein found in nearly all human and animal cells. TB-500 represents the active region of Thymosin Beta-4 responsible for actin-binding properties, composed of a 17-amino acid sequence (residues 17-23 of the parent Tβ4 protein). This compound has been the subject of substantial cellular and biochemical research literature.
Each vial contains 10mg of lyophilized TB-500 in a sealed 3mL glass vial, manufactured in cGMP-compliant facilities and verified through Mile High Compounds’ three-tier quality protocol: 7x independent third-party analytical testing, 4-vial batch conformity verification, and comprehensive heavy metal screening.
Product Specifications
- Compound: TB-500 (Thymosin Beta-4 fragment)
- Class: Synthetic peptide fragment of Thymosin Beta-4
- Parent Protein: Thymosin Beta-4 (Tβ4), 43 amino acids
- Molecular Weight: ~889 Da
- Form: Lyophilized powder
- Vial Size: 10mg in 3mL glass vial
- Purity: 99%+ verified by HPLC and mass spectrometry (See COAs)
- Manufacturing: cGMP-compliant facility, United States
Research Background
TB-500 has been investigated in research literature across several scientific contexts:
- Actin binding and cellular cytoskeleton research — investigations into the peptide’s role in actin sequestration and cytoskeletal dynamics
- Cellular migration and tissue research — studies examining cellular response in tissue models including endothelial, epithelial, and fibroblast cell lines
- Angiogenesis pathway research — cellular signaling research involving vascular development and growth factor interactions
- Inflammation pathway investigations — studies on cellular inflammatory response and cytokine signaling
- Comparative peptide research — analytical chemistry studies examining TB-500 fragment behavior compared to full-length Thymosin Beta-4
A substantial body of peer-reviewed research on Thymosin Beta-4 and its derivative fragments including TB-500 exists in scientific literature. Foundational research is available through PubMed (pubmed.ncbi.nlm.nih.gov) and the National Institutes of Health’s PMC database (pmc.ncbi.nlm.nih.gov), where researchers can access peer-reviewed studies examining:
- Goldstein et al., foundational research on Thymosin Beta-4 cellular biology and its derivative peptides
- Research on actin-binding domain function and cytoskeletal cellular dynamics
- Comparative studies of TB-500 fragment activity in cellular and animal research models
Researchers seeking comprehensive literature reviews can access the full body of Thymosin Beta-4 and TB-500 research via NIH/PubMed databases.
Analytical Verification
Every batch undergoes Mile High Compounds’ comprehensive analytical protocol:
- High-Performance Liquid Chromatography (HPLC) for purity quantification
- Mass Spectrometry (MS) for molecular weight and identity confirmation
- 14-day sterility testing
- Endotoxin analysis
- 4-vial batch conformity verification — statistically robust consistency testing across each production batch, exceeding the industry-standard single-vial sampling approach
- Heavy metal screening for lead, arsenic, cadmium, mercury, and additional trace metals
- Container and seal integrity verification
Batch-specific Certificates of Analysis (COAs) accompany every order, documenting full testing results across all verification protocols.
Reconstitution and Storage
- Lyophilized storage: Cool, dry location away from direct light; -20°C for long-term stability
- Post-reconstitution: Refrigerate at 2-8°C, protect from light
- Reconstituted use window: 30 days for optimal research integrity
- Avoid: Repeated freeze-thaw cycles
Quality Standards
Mile High Compounds maintains a rigorous quality control framework across all research compounds. Our multi-layered testing protocol provides researchers with verified, high-purity reference materials supported by complete analytical documentation.
- 7x independent third-party testing per batch
- 4-vial batch conformity verification
- Heavy metal screening for trace contaminant analysis
- cGMP-compliant manufacturing
- Full analytical traceability
- Same-day shipping for orders placed before 3PM MST
Terms of Sale
This product is supplied for in vitro laboratory research only and has not been evaluated by the U.S. Food and Drug Administration. By purchasing, the buyer confirms they are 21 or older, a qualified research professional or institution, and will not use this material for human consumption, veterinary use, or any in vivo application. Mile High Compounds assumes no liability for misuse or off-label application.
About Mile High Compounds
Colorado-based research compound supplier specializing in high-purity reference materials for laboratory applications. Every batch undergoes our three-tier quality protocol: 7x independent third-party analytical verification, 4-vial batch conformity testing, and comprehensive heavy metal screening — manufactured in cGMP-compliant U.S. facilities.
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