Semax

Semax 10mg

Semax is a synthetic heptapeptide (seven amino acids) developed in the 1980s by Russian peptide research laboratories as a synthetic analog of the natural ACTH (4-10) fragment. With the sequence Met-Glu-His-Phe-Pro-Gly-Pro, Semax represents a modified ACTH fragment structurally designed to enhance peptide stability and resistance to enzymatic degradation compared to native ACTH sequences. Semax has been the subject of substantial cellular neurobiology and biochemical research literature.

Each vial contains 10mg of lyophilized Semax in a sealed 3mL glass vial, verified through Mile High Compounds’ three-tier quality protocol: 7x independent third-party analytical testing, 4-vial batch conformity verification, and comprehensive heavy metal screening.

Product Specifications

• Compound: Semax
• Class: Synthetic heptapeptide / ACTH (4-10) analog
• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
• Molecular Weight: ~813 Da
• Form: Lyophilized powder
• Vial Size: 10mg in 3mL glass vial
• Purity: 99%+ verified by HPLC and mass spectrometry (See COAs)

Research Background

Semax has been investigated in research literature across several scientific contexts:

• Cellular neurobiology research — investigations into peptide effects on cellular signaling pathways in neuronal cell models
• BDNF and neurotrophin pathway research — studies examining cellular responses involving brain-derived neurotrophic factor (BDNF) signaling cascades in cell culture systems
• Melanocortin receptor research — peptide pharmacology studies on ACTH-derived peptide fragments and their receptor binding profiles
• Peptide stability engineering — comparative research on Semax vs. native ACTH (4-10) examining how structural modifications affect peptide half-life and enzymatic resistance
• Cellular oxidative stress research — studies examining cellular response in neuronal models under oxidative conditions
• Comparative neuropeptide research — analytical studies positioning Semax alongside related research peptides in cellular contexts

Semax was originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and has been studied extensively in peer-reviewed research published by the Myasoedov research group and other Russian peptide research laboratories. Foundational research is available through PubMed (pubmed.ncbi.nlm.nih.gov) and the National Institutes of Health’s PMC database (pmc.ncbi.nlm.nih.gov), where researchers can access peer-reviewed studies on Semax cellular biology and ACTH-derived peptide research.

Analytical Verification

Every batch undergoes Mile High Compounds’ comprehensive analytical protocol:

• High-Performance Liquid Chromatography (HPLC) for purity quantification
• Mass Spectrometry (MS) for molecular weight and identity confirmation
• 14-day sterility testing
• Endotoxin analysis
• 4-vial batch conformity verification — statistically robust consistency testing across each production batch, exceeding the industry-standard single-vial sampling approach
• Heavy metal screening for lead, arsenic, cadmium, mercury, and additional trace metals
• Container and seal integrity verification

Batch-specific Certificates of Analysis (COAs) accompany every order, documenting full testing results across all verification protocols.

Reconstitution and Storage

• Lyophilized storage: Cool, dry location away from direct light; -20°C for long-term stability
• Post-reconstitution: Refrigerate at 2-8°C, protect from light
• Reconstituted use window: 30 days for optimal research integrity
• Avoid: Repeated freeze-thaw cycles to preserve compound stability and structural integrity

Quality Standards

Mile High Compounds maintains a rigorous quality control framework across all research compounds. Our multi-layered testing protocol provides researchers with verified, high-purity reference materials supported by complete analytical documentation.

• 7x independent third-party testing per batch
• 4-vial batch conformity verification
• Heavy metal screening for trace contaminant analysis
• cGMP-compliant manufacturing
• Full analytical traceability
• Same-day shipping for orders placed before 3PM MST

Terms of Sale

This product is supplied for in vitro laboratory research only and has not been evaluated by the U.S. Food and Drug Administration. By purchasing, the buyer confirms they are 21 or older, a qualified research professional or institution, and will not use this material for human consumption, veterinary use, or any in vivo application. Mile High Compounds assumes no liability for misuse or off-label application.

About Mile High Compounds

Colorado-based research compound supplier specializing in high-purity reference materials for laboratory applications. Every batch undergoes our three-tier quality protocol: 7x independent third-party analytical verification, 4-vial batch conformity testing, and comprehensive heavy metal screening — manufactured in cGMP-compliant facilities.

Trusted by the research community with 4.9-star Trustpilot & PepReviewPro ratings and over 700+ verified customer reviews.