MOTS-c

MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene. Identified by the Cohen Lab at the University of Southern California in 2015, MOTS-c represents an emerging class of mitochondrial-derived peptides (MDPs) and has been the subject of substantial cellular biology and biochemical research literature examining mitochondrial signaling, cellular metabolism, and metabolic regulatory pathways.

Available in 10mg and 40mg variants supplied as lyophilized powder in sealed 3mL glass vials, verified through Mile High Compounds’ three-tier quality protocol: 7x independent third-party analytical testing, 4-vial batch conformity verification, and comprehensive heavy metal screening.

Product Specifications

• Compound: MOTS-c (Mitochondrial-derived peptide)
• Class: 16-amino acid mitochondrial-derived peptide (MDP)
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Molecular Weight: ~2174 Da
• Form: Lyophilized powder
• Vial Configurations:
  • 10mg in 3mL glass vial
  • 40mg in 3mL glass vial
• Purity: 99%+ verified by HPLC and mass spectrometry (See COAs)

Research Background

MOTS-c has been investigated in research literature across several scientific contexts:

• Mitochondrial-derived peptide biology — investigations into the broader class of peptides encoded within mitochondrial DNA, including MOTS-c, humanin, and SHLP family peptides
• Mitochondrial-nuclear signaling research — studies examining how mitochondrial-derived peptides communicate with nuclear cellular pathways
• Cellular metabolism and AMPK pathway research — research examining MOTS-c’s role in AMP-activated protein kinase (AMPK) cellular signaling and metabolic regulation
• Cellular aging and metabolic research — studies investigating MOTS-c levels across cellular aging models and metabolic states
• Exercise and skeletal muscle cellular research — research literature examining MOTS-c expression in cellular response to exercise stress in cellular and animal models

MOTS-c is notable in research literature as one of the first identified mitochondrial-derived peptides and represents an emerging area of cellular biology research. Foundational discovery research was published by Lee et al. (Cohen Lab, University of Southern California) in Cell Metabolism (2015), and subsequent research has been published across high-impact journals including Nature Communications, Cell Reports, and others. Researchers seeking comprehensive literature can access the full body of MOTS-c research through PubMed (pubmed.ncbi.nlm.nih.gov) and the National Institutes of Health’s PMC database (pmc.ncbi.nlm.nih.gov).

Analytical Verification

Every batch undergoes Mile High Compounds’ comprehensive analytical protocol:

• High-Performance Liquid Chromatography (HPLC) for purity quantification
• Mass Spectrometry (MS) for molecular weight and identity confirmation
• 14-day sterility testing
• Endotoxin analysis
• 4-vial batch conformity verification — statistically robust consistency testing across each production batch, exceeding the industry-standard single-vial sampling approach
• Heavy metal screening for lead, arsenic, cadmium, mercury, and additional trace metals
• Container and seal integrity verification

Batch-specific Certificates of Analysis (COAs) accompany every order, documenting full testing results across all verification protocols.

Reconstitution and Storage

• Lyophilized storage: Cool, dry location away from direct light; -20°C for long-term stability
• Post-reconstitution: Refrigerate at 2-8°C, protect from light
• Reconstituted use window: 30 days for optimal research integrity
• Avoid: Repeated freeze-thaw cycles to preserve compound stability and structural integrity

Quality Standards

Mile High Compounds maintains a rigorous quality control framework across all research compounds. Our multi-layered testing protocol provides researchers with verified, high-purity reference materials supported by complete analytical documentation.

• 7x independent third-party testing per batch
• 4-vial batch conformity verification
• Heavy metal screening for trace contaminant analysis
• cGMP-compliant manufacturing
• Full analytical traceability
• Same-day shipping for orders placed before 3PM MST

Terms of Sale

This product is supplied for in vitro laboratory research only and has not been evaluated by the U.S. Food and Drug Administration. By purchasing, the buyer confirms they are 21 or older, a qualified research professional or institution, and will not use this material for human consumption, veterinary use, or any in vivo application. Mile High Compounds assumes no liability for misuse or off-label application.

About Mile High Compounds

Colorado-based research compound supplier specializing in high-purity reference materials for laboratory applications. Every batch undergoes our three-tier quality protocol: 7x independent third-party analytical verification, 4-vial batch conformity testing, and comprehensive heavy metal screening — manufactured in cGMP-compliant facilities.

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